SIVcpz in wild chimpanzees.
نویسندگان
چکیده
Mario L. Santiago, Cynthia M. Rodenburg, Shadrack Kamenya, Frederic Bibollet-Ruche, Feng Gao, Elizabeth Bailes, Sreelatha Meleth, Seng-Jaw Soong, J. Michael Kilby, Zina Moldoveanu, Babette Fahey, Martin N. Muller, Ahidjo Ayouba, Eric Nerrienet, Harold M. McClure, Jonathan L. Heeney, Anne E. Pusey, D. Anthony Collins, Christophe Boesch, Richard W. Wrangham, Jane Goodall, Paul M. Sharp, George M. Shaw, Beatrice H. Hahn*
منابع مشابه
High prevalence of simian immunodeficiency virus infection in a community of savanna chimpanzees.
Simian immunodeficiency virus of chimpanzees (SIVcpz) has a significant negative impact on the health, reproduction, and life span of chimpanzees, yet the prevalence and distribution of this virus in wild-living populations are still only poorly understood. Here, we show that savanna chimpanzees, who live in ecologically marginal habitats at 10- to 50-fold lower population densities than forest...
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Human immunodeficiency virus type 1 (HIV-1) group N from Cameroon is phylogenetically close, in env, to the simian immunodeficiency virus (SIV) cpz-gab from Gabon and SIVcpz-US of unknown geographic origin. We screened 29 wild-born Cameroonian chimpanzees and found that three (Cam3, Cam4, and Cam5) were positive for HIV-1 by Western blotting. Mitochondrial DNA sequence analysis demonstrated tha...
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Current knowledge of the genetic diversity of simian immunodeficiency virus (SIVcpz) infection of wild chimpanzees (Pan troglodytes) is incomplete since few isolates, mostly from captive apes from Cameroon and Gabon, have been characterized; yet this information is critical for understanding the origins of human immunodeficiency virus type 1 (HIV-1) and the circumstances leading to the HIV-1 pa...
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Studies of primate lentiviruses continue to provide information about the evolution of simian immunodeficiency viruses (SIVs) and the origin and emergence of HIV since chimpanzees in west-central Africa (Pan troglodytes troglodytes) were recognized as the reservoir of SIVcpzPtt viruses, which have been related phylogenetically to HIV-1. Using in-house peptide ELISAs to study SIV prevalence, we ...
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Human immunodeficiency virus type 1 (HIV-1) evolved via cross-species transmission of simian immunodeficiency virus (SIVcpz) from chimpanzees (Pan troglodytes). Chimpanzees, like humans, are susceptible to infection by HIV-1. However, unlike humans, infected chimpanzees seldom develop immunodeficiency when infected with SIVcpz or HIV-1. SIVcpz and most strains of HIV-1 require the cell-surface ...
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Major histocompatibility complex (MHC) class I molecules determine immune responses to viral infections. These polymorphic cell-surface glycoproteins bind peptide antigens, forming ligands for cytotoxic T and natural killer cell receptors. Under pressure from rapidly evolving viruses, hominoid MHC class I molecules also evolve rapidly, becoming diverse and species-specific. Little is known of t...
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ورودعنوان ژورنال:
- Science
دوره 295 5554 شماره
صفحات -
تاریخ انتشار 2002